Gene Regulation, Stems Cells and Cancer

fatima-gebaure
Regulation of Protein Synthesis in Eukaryotes

Group Structure

GROUP LEADER:
Fátima Gebauer
LAB MANAGER:
Olga Coll
POSTDOCTORAL RESEARCHERS:
Laurence Wurth, Tanit Guitart
PhD STUDENTS:
Emilia Szostak, Marina García, Himapriyanka Nadimpali, Marta Inglés, Technician

Summary

Our group is interested in molecular mechanisms of translational control exerted by RNA-binding proteins (RBPs), the broader functions of RBPs at other steps of gene expression, and how RBP alterations contribute to cancer progression. We use examples ranging from embryonic development in Drosophila to human cells, with the aim to inform general principles of regulation.
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Research Projects

  • Molecular mechanisms of msl2 translational repression.
  • Role of RNA binding proteins in Drosophila X-chromosome dosage compensation.
  • Cytoplasmic polyadenylation in early Drosophila embryos.
  • Role of UNR in cancer progression.

Selected Publications

  1. Graindorge A, Carré C, Gebauer F.
    “Sex-lethal promotes nuclear retention of msl2 mRNA via interactions with the STAR protein HOW.”
    Genes Dev, 27(12):1421-33 (2013).
  2. Szostak E, Gebauer F.
    “Translational control by 3′-UTR-binding proteins.”
    Brief Funct Genomics, 12(1):58-65 (2013). Review.